TNFSF8 Full-Length MS Protein Standard


Product Description:

Name TNFSF8 Full-Length MS Protein Standard
Cat# CPFL311276
Protein Nametumor necrosis factor (ligand) superfamily, member 8
SymbolTNFSF8
SynonymsCD153; CD30L; CD30LG
AccessionNM_001244
Cytogenetic9q33
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW25.8 kDa
Expression TrueORF CloneRC211276
DescriptionTNFSF8 Full-Length MS Protein Standard (NP_001235), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkins and some non-Hodgkins lymphomas. Two transcript variants encoding different isoforms have been found for this gene.

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