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GEMIN2 Full-Length MS Protein Standard

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Product Description


NameGEMIN2 Full-Length MS Protein Standard
Cat#CPFL311219
Protein NameGEMIN2 gem (nuclear organelle) associated protein 2
SymbolGEMIN2
SynonymsSIP1; SIP1-delta
AccessionNM_003616
Cytogenetic14q13
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionSIP1 Full-Length MS Protein Standard (NP_003607), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.

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