BCL2L2 Full-Length MS Protein Standard


Product Description:

Name BCL2L2 Full-Length MS Protein Standard
Cat# CPFL311152
Protein NameBCL2-like 2
SymbolBCL2L2
SynonymsBCL-W; BCL2-L-2; BCLW; PPP1R51
AccessionNM_004050
Cytogenetic14q11.2-q12
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW20.6 kDa
Expression TrueORF CloneRC211152
DescriptionBCL2L2 Full-Length MS Protein Standard (NP_004041), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.

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