COMP Full-Length MS Protein Standard


Product Description:

Name COMP Full-Length MS Protein Standard
Cat# CPFL311080
Protein Namecartilage oligomeric matrix protein
SymbolCOMP
SynonymsEDM1; EPD1; MED; PSACH; THBS5
AccessionNM_000095
Cytogenetic19p13.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW80.9 kDa
Expression TrueORF CloneRC211080
DescriptionCOMP Full-Length MS Protein Standard (NP_000086), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).

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