CYP7A1 Full-Length MS Protein Standard


Product Description:

Name CYP7A1 Full-Length MS Protein Standard
Cat# CPFL311019
Protein Namecytochrome P450, family 7, subfamily A, polypeptide 1
SymbolCYP7A1
SynonymsCP7A; CYP7; CYPVII
AccessionNM_000780
Cytogenetic8q11-q12
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW57.5 kDa
Expression TrueORF CloneRC211019
DescriptionCYP7A1 Full-Length MS Protein Standard (NP_000771), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis.

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