LIG1 Full-Length MS Protein Standard


Product Description:

Name LIG1 Full-Length MS Protein Standard
Cat# CPFL310760
Protein Nameligase I, DNA, ATP-dependent
SymbolLIG1
SynonymsMGC117397; MGC130025
AccessionNM_000234
Cytogenetic19q13.2-q13.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW101.6 kDa
Expression TrueORF CloneRC210760
DescriptionLIG1 Full-Length MS Protein Standard (NP_000225), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.

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