RAE1 Full-Length MS Protein Standard


Product Description:

Name RAE1 Full-Length MS Protein Standard
Cat# CPFL310733
Protein NameRAE1 RNA export 1 homolog (S. pombe)
SymbolRAE1
SynonymsdJ481F12.3; dJ800J21.1; MIG14; Mnrp41; MRNP41
AccessionNM_001015885
Cytogenetic20q13.31
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW40.8 kDa
Expression TrueORF CloneRC210733
DescriptionRAE1 Full-Length MS Protein Standard (NP_001015885), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

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