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OTUB1 Full-Length MS Protein Standard

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Product Description


NameOTUB1 Full-Length MS Protein Standard
Cat#CPFL310648
Protein NameOTU domain, ubiquitin aldehyde binding 1
SymbolOTUB1
SynonymsHSPC263; OTB1; OTU1
AccessionNM_017670
Cytogenetic11q13.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionOTUB1 Full-Length MS Protein Standard (NP_060140), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.

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