Home > Products > Stable Isotope Labeled Full Length MS Protein Standard > DUT Full-Length MS Protein Standard

DUT Full-Length MS Protein Standard

INQUIRY>

Product Description


NameDUT Full-Length MS Protein Standard
Cat#CPFL310600
Protein Namedeoxyuridine triphosphatase
SymbolDUT
SynonymsdUTPase
AccessionNM_001025249
Cytogenetic15q21.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionDUT Full-Length MS Protein Standard (NP_001020420), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.

Products List:

Cat#Protein SequencePrice

If the product of interest is not available in our catalog, we can synthesize for you with our quality controlled
Customized Synthesized Peptide/Proteins Service!

Online Inquiry


Please input "proteomics" as verification code.