BCL7A Full-Length MS Protein Standard


Product Description:

Name BCL7A Full-Length MS Protein Standard
Cat# CPFL310489
Protein NameB-cell CLL/lymphoma 7A
SymbolBCL7A
SynonymsBCL7
AccessionNM_001024808
Cytogenetic12q24.13
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW22.6 kDa
Expression TrueORF CloneRC210489
DescriptionBCL7A Full-Length MS Protein Standard (NP_001019979), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene.

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