RPE65 Full-Length MS Protein Standard
Product Description:
| Name |
RPE65 Full-Length MS Protein Standard |
| Cat# |
CPFL310433 |
| Protein Name | retinal pigment epithelium-specific protein 65kDa |
| Symbol | RPE65 |
| Synonyms | BCO3; LCA2; mRPE65; rd12; RP20; sRPE65 |
| Accession | NM_000329 |
| Cytogenetic | 1p31 |
| Amino Acid Labeled | [U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys |
| Chemical Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Expression Host | Human HEK293 cells |
| Predicted MW | 61.4 kDa |
| Expression TrueORF Clone | RC210433 |
| Description | RPE65 Full-Length MS Protein Standard (NP_000320), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. |
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