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ASIC2 Full-Length MS Protein Standard

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Product Description


NameASIC2 Full-Length MS Protein Standard
Cat#CPFL310409
Protein Nameacid-sensing (proton-gated) ion channel 2
SymbolASIC2
SynonymsACCN; ACCN1; ASIC2a; BNaC1; BNC1; hBNaC1; MDEG
AccessionNM_001094
Cytogenetic17q12
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionACCN1 Full-Length MS Protein Standard (NP_001085), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified.

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