RRM2B Full-Length MS Protein Standard


Product Description:

Name RRM2B Full-Length MS Protein Standard
Cat# CPFL310340
Protein Nameribonucleotide reductase M2 B (TP53 inducible)
SymbolRRM2B
SynonymsMTDPS8A; MTDPS8B; P53R2
AccessionNM_015713
Cytogenetic8q23.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW40.6 kDa
Expression TrueORF CloneRC210340
DescriptionRRM2B Full-Length MS Protein Standard (NP_056528), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.

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