ADRBK1 Full-Length MS Protein Standard


Product Description:

Name ADRBK1 Full-Length MS Protein Standard
Cat# CPFL310327
Protein Nameadrenergic, beta, receptor kinase 1
SymbolADRBK1
SynonymsBARK1; BETA-ARK1; GRK2
AccessionNM_001619
Cytogenetic11q13.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW79.4 kDa
Expression TrueORF CloneRC210327
DescriptionADRBK1 Full-Length MS Protein Standard (NP_001610), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

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