CYP2C18 Full-Length MS Protein Standard


Product Description:

Name CYP2C18 Full-Length MS Protein Standard
Cat# CPFL310231
Protein Namecytochrome P450, family 2, subfamily C, polypeptide 18
SymbolCYP2C18
SynonymsCPCI; CYP2C; CYP2C17; P450-6B/29C; P450IIC17
AccessionNM_000772
Cytogenetic10q24
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW55.5 kDa
Expression TrueORF CloneRC210231
DescriptionCYP2C18 Full-Length MS Protein Standard (NP_000763), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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