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APP Full-Length MS Protein Standard

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Product Description


NameAPP Full-Length MS Protein Standard
Cat#CPFL309575
Protein Nameamyloid beta (A4) precursor protein
SymbolAPP
SynonymsAAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
AccessionNM_201413
Cytogenetic21q21.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionAPP Full-Length MS Protein Standard (NP_958816), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

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