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UNC13D Full-Length MS Protein Standard

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Product Description


NameUNC13D Full-Length MS Protein Standard
Cat#CPFL309141
Protein Nameunc-13 homolog D
SymbolUNC13D
SynonymsFHL3; HLH3; HPLH3; Munc13-4
AccessionNM_199242
Cytogenetic17q25.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionUNC13D Full-Length MS Protein Standard (NP_954712), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.

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