UNC13D Full-Length MS Protein Standard
Product Description:
| Name |
UNC13D Full-Length MS Protein Standard |
| Cat# |
CPFL309141 |
| Protein Name | unc-13 homolog D |
| Symbol | UNC13D |
| Synonyms | FHL3; HLH3; HPLH3; Munc13-4 |
| Accession | NM_199242 |
| Cytogenetic | 17q25.1 |
| Amino Acid Labeled | [U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys |
| Chemical Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Expression Host | Human HEK293 cells |
| Predicted MW | 123.1 kDa |
| Expression TrueORF Clone | RC209141 |
| Description | UNC13D Full-Length MS Protein Standard (NP_954712), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. |
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