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PAFAH1B1 Full-Length MS Protein Standard

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Product Description


NamePAFAH1B1 Full-Length MS Protein Standard
Cat#CPFL309055
Protein Nameplatelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
SymbolPAFAH1B1
SynonymsLIS1; LIS2; MDCR; MDS; PAFAH
AccessionNM_000430
Cytogenetic17p13.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionPAFAH1B1 Full-Length MS Protein Standard (NP_000421), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum.

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