ZAP70 Full-Length MS Protein Standard


Product Description:

Name ZAP70 Full-Length MS Protein Standard
Cat# CPFL308838
Protein NameZAP70 zeta-chain (TCR) associated protein kinase 70kDa
SymbolZAP70
SynonymsSRK; STCD; STD; TZK; ZAP-70
AccessionNM_001079
Cytogenetic2q12
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW69.7 kDa
Expression TrueORF CloneRC208838
DescriptionZAP70 Full-Length MS Protein Standard (NP_001070), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

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