ARHGEF11 Full-Length MS Protein Standard


Product Description:

Name ARHGEF11 Full-Length MS Protein Standard
Cat# CPFL308729
Protein NameRho guanine nucleotide exchange factor (GEF) 11
SymbolARHGEF11
SynonymsGTRAP48; PDZ-RHOGEF
AccessionNM_198236
Cytogenetic1q21
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW172.1 kDa
Expression TrueORF CloneRC208729
DescriptionARHGEF11 Full-Length MS Protein Standard (NP_937879), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.

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