MTHFR Full-Length MS Protein Standard


Product Description:

Name MTHFR Full-Length MS Protein Standard
Cat# CPFL308588
Protein Namemethylenetetrahydrofolate reductase (NAD(P)H)
SymbolMTHFR
SynonymsOTTHUMP00000002367; OTTHUMP00000002368; methylenetetrahydrofolate reductase intermediate form; 5,10-methylenetetrahydrofolate reductase (NADPH)
AccessionNM_005957
Cytogenetic1p36.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW74.4 kDa
Expression TrueORF CloneRC208588
DescriptionMTHFR Full-Length MS Protein Standard (NP_005948), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.

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