TIMELESS Full-Length MS Protein Standard


Product Description:

Name TIMELESS Full-Length MS Protein Standard
Cat# CPFL308527
Protein Nametimeless homolog (Drosophila)
SymbolTIMELESS
SynonymshTIM; TIM; TIM1
AccessionNM_003920
Cytogenetic12q13.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW138.5 kDa
Expression TrueORF CloneRC208527
DescriptionTIMELESS Full-Length MS Protein Standard (NP_003911), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders.

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