NR1H2 Full-Length MS Protein Standard


Product Description:

Name NR1H2 Full-Length MS Protein Standard
Cat# CPFL308381
Protein Namenuclear receptor subfamily 1, group H, member 2
SymbolNR1H2
SynonymsLXR-b; LXRB; NER; NER-I; RIP15; UNR
AccessionNM_007121
Cytogenetic19q13.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW50.9 kDa
Expression TrueORF CloneRC208381
DescriptionNR1H2 Full-Length MS Protein Standard (NP_009052), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 )

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