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HMGCS2 Full-Length MS Protein Standard

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Product Description


NameHMGCS2 Full-Length MS Protein Standard
Cat#CPFL308128
Protein Name3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
SymbolHMGCS2
SynonymsOTTHUMP00000013928; hydroxymethylglutaryl-CoA synthase 2; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
AccessionNM_005518
Cytogenetic1p13-p12
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionHMGCS2 Full-Length MS Protein Standard (NP_005509), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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