VPS4A Full-Length MS Protein Standard


Product Description:

Name VPS4A Full-Length MS Protein Standard
Cat# CPFL308099
Protein Namevacuolar protein sorting 4 homolog A (S. cerevisiae)
SymbolVPS4A
SynonymsSKD1; SKD1A; SKD2; VPS4; VPS4-1
AccessionNM_013245
Cytogenetic16q22.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW48.7 kDa
Expression TrueORF CloneRC208099
DescriptionVPS4A Full-Length MS Protein Standard (NP_037377), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.

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