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UPF1 Full-Length MS Protein Standard

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Product Description


NameUPF1 Full-Length MS Protein Standard
Cat#CPFL308018
Protein NameUPF1 regulator of nonsense transcripts homolog (yeast)
SymbolUPF1
SynonymsHUPF1; NORF1; pNORF1; RENT1; smg-2
AccessionNM_002911
Cytogenetic19p13.2-p13.11
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionUPF1 Full-Length MS Protein Standard (NP_002902), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.

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