P4HA2 Full-Length MS Protein Standard


Product Description:

Name P4HA2 Full-Length MS Protein Standard
Cat# CPFL307779
Protein Nameprolyl 4-hydroxylase, alpha polypeptide II
SymbolP4HA2
Synonyms4-PH alpha 2
AccessionNM_001017973
Cytogenetic5q31
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW58.2 kDa
Expression TrueORF CloneRC207779
DescriptionP4HA2 Full-Length MS Protein Standard (NP_001017973), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.

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