XIAP Full-Length MS Protein Standard


Product Description:

Name XIAP Full-Length MS Protein Standard
Cat# CPFL307627
Protein NameX-linked inhibitor of apoptosis
SymbolXIAP
SynonymsAPI3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1; MIHA; XLP2
AccessionNM_001167
CytogeneticXq25
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW56.5 kDa
Expression TrueORF CloneRC207627
DescriptionXIAP Full-Length MS Protein Standard (NP_001158), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.

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