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CYP3A5 Full-Length MS Protein Standard

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Product Description


NameCYP3A5 Full-Length MS Protein Standard
Cat#CPFL307432
Protein Namecytochrome P450, family 3, subfamily A, polypeptide 5
SymbolCYP3A5
SynonymsCP35; CYPIIIA5; P450PCN3; PCN3
AccessionNM_000777
Cytogenetic7q21.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionCYP3A5 Full-Length MS Protein Standard (NP_000768), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants.

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