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FIG4 Full-Length MS Protein Standard

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Product Description


NameFIG4 Full-Length MS Protein Standard
Cat#CPFL307192
Protein NameFIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
SymbolFIG4
SynonymsALS11; BTOP; CMT4J; dJ249I4.1; KIAA0274; SAC3; YVS
AccessionNM_014845
Cytogenetic6q21
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionFIG4 Full-Length MS Protein Standard (NP_055660), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J.

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