TIRAP Full-Length MS Protein Standard


Product Description:

Name TIRAP Full-Length MS Protein Standard
Cat# CPFL307162
Protein Nametoll-interleukin 1 receptor (TIR) domain containing adaptor protein
SymbolTIRAP
SynonymsBACTS1; Mal; MyD88-2; wyatt
AccessionNM_001039661
Cytogenetic11q24.2
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW23.7 kDa
Expression TrueORF CloneRC207162
DescriptionTIRAP Full-Length MS Protein Standard (NP_001034750), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

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