MAP2K3 Full-Length MS Protein Standard


Product Description:

Name MAP2K3 Full-Length MS Protein Standard
Cat# CPFL307115
Protein Namemitogen-activated protein kinase kinase 3
SymbolMAP2K3
SynonymsMAPKK3; MEK3; MKK3; PRKMK3; SAPKK-2; SAPKK2
AccessionNM_145109
Cytogenetic17q11.2
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW39.1 kDa
Expression TrueORF CloneRC207115
DescriptionMAP2K3 Full-Length MS Protein Standard (NP_659731), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.

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