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LMAN1 Full-Length MS Protein Standard

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Product Description


NameLMAN1 Full-Length MS Protein Standard
Cat#CPFL307088
Protein Namelectin, mannose-binding, 1
SymbolLMAN1
SynonymsERGIC-53; ERGIC53; F5F8D; FMFD1; gp58; MCFD1; MR60
AccessionNM_005570
Cytogenetic18q21.3-q22
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionLMAN1 Full-Length MS Protein Standard (NP_005561), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.

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