IL10RA Full-Length MS Protein Standard


Product Description:

Name IL10RA Full-Length MS Protein Standard
Cat# CPFL307020
Protein Nameinterleukin 10 receptor, alpha
SymbolIL10RA
SynonymsCD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R
AccessionNM_001558
Cytogenetic11q23
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW60.8 kDa
Expression TrueORF CloneRC207020
DescriptionIL10RA Full-Length MS Protein Standard (NP_001549), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.

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