BUB1 Full-Length MS Protein Standard


Product Description:

Name BUB1 Full-Length MS Protein Standard
Cat# CPFL307013
Protein NameBUB1 mitotic checkpoint serine/threonine kinase
SymbolBUB1
SynonymsBUB1A; BUB1L; hBUB1
AccessionNM_004336
Cytogenetic2q14
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW122.2 kDa
Expression TrueORF CloneRC207013
DescriptionBUB1 Full-Length MS Protein Standard (NP_004327), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants.

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