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GRB10 Full-Length MS Protein Standard

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Product Description


NameGRB10 Full-Length MS Protein Standard
Cat#CPFL306853
Protein Namegrowth factor receptor-bound protein 10
SymbolGRB10
SynonymsGrb-10; GRB-IR; IRBP; MEG1; RSS
AccessionNM_001001555
Cytogenetic7p12.2
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionGRB10 Full-Length MS Protein Standard (NP_001001555), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified.

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