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NGEF Full-Length MS Protein Standard

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Product Description


NameNGEF Full-Length MS Protein Standard
Cat#CPFL306775
Protein Nameneuronal guanine nucleotide exchange factor
SymbolNGEF
SynonymsARHGEF27; EPHEXIN
AccessionNM_019850
Cytogenetic2q37
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionNGEF Full-Length MS Protein Standard (NP_062824), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.

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