IL3RA Full-Length MS Protein Standard


Product Description:

Name IL3RA Full-Length MS Protein Standard
Cat# CPFL306420
Protein Nameinterleukin 3 receptor, alpha (low affinity)
SymbolIL3RA
SynonymsCD123; hIL-3Ra; IL3R; IL3RAY; IL3RX; IL3RY
AccessionNM_002183
CytogeneticXp22.3 or Yp11.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW41.2 kDa
Expression TrueORF CloneRC206420
DescriptionIL3RA Full-Length MS Protein Standard (NP_002174), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.

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