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PDGFRB Full-Length MS Protein Standard

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Product Description


NamePDGFRB Full-Length MS Protein Standard
Cat#CPFL306377
Protein Nameplatelet derived growth factor receptor, beta polypeptide
SymbolPDGFRB
SynonymsCD140B; IBGC4; IMF1; JTK12; PDGFR; PDGFR-1; PDGFR1
AccessionNM_002609
Cytogenetic5q33.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionPDGFRB Full-Length MS Protein Standard (NP_002600), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

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