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CTPS2 Full-Length MS Protein Standard

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Product Description


NameCTPS2 Full-Length MS Protein Standard
Cat#CPFL305993
Protein NameCTP synthase II
SymbolCTPS2
SynonymsDKFZp686C17207; FLJ43358; MGC32997
AccessionNM_019857
CytogeneticXp22
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionCTPS2 Full-Length MS Protein Standard (NP_062831), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants.

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