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NEFL Full-Length MS Protein Standard

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Product Description


NameNEFL Full-Length MS Protein Standard
Cat#CPFL305920
Protein Nameneurofilament, light polypeptide
SymbolNEFL
SynonymsCMT1F; CMT2E; NF-L; NF68; NFL; PPP1R110
AccessionNM_006158
Cytogenetic8p21
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionNEFL Full-Length MS Protein Standard (NP_006149), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.

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