CYP1A1 Full-Length MS Protein Standard


Product Description:

Name CYP1A1 Full-Length MS Protein Standard
Cat# CPFL305760
Protein Namecytochrome P450, family 1, subfamily A, polypeptide 1
SymbolCYP1A1
SynonymsAHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
AccessionNM_000499
Cytogenetic15q24.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW58 kDa
Expression TrueORF CloneRC205760
DescriptionCYP1A1 Full-Length MS Protein Standard (NP_000490), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzymes endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.

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