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NR1I2 Full-Length MS Protein Standard

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Product Description


NameNR1I2 Full-Length MS Protein Standard
Cat#CPFL305691
Protein Namenuclear receptor subfamily 1, group I, member 2
SymbolNR1I2
SynonymsBXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR
AccessionNM_003889
Cytogenetic3q12-q13.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionNR1I2 Full-Length MS Protein Standard (NP_003880), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

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