CYP46A1 Full-Length MS Protein Standard


Product Description:

Name CYP46A1 Full-Length MS Protein Standard
Cat# CPFL305446
Protein Namecytochrome P450, family 46, subfamily A, polypeptide 1
SymbolCYP46A1
SynonymsCP46; CYP46
AccessionNM_006668
Cytogenetic14q32.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW56.6 kDa
Expression TrueORF CloneRC205446
DescriptionCYP46A1 Full-Length MS Protein Standard (NP_006659), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.

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