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TJP2 Full-Length MS Protein Standard

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Product Description


NameTJP2 Full-Length MS Protein Standard
Cat#CPFL305295
Protein Nametight junction protein 2 (zona occludens 2)
SymbolTJP2
SynonymsC9DUPq21.11; DFNA51; DUP9q21.11; PFIC4; X104; ZO2
AccessionNM_004817
Cytogenetic9q13-q21
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionTJP2 Full-Length MS Protein Standard (NP_004808), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

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