HARS2 Full-Length MS Protein Standard


Product Description:

Name HARS2 Full-Length MS Protein Standard
Cat# CPFL304925
Protein Namehistidyl-tRNA synthetase 2, mitochondrial (putative)
SymbolHARS2
SynonymsHARSL; HARSR; HO3; PRLTS2
AccessionNM_012208
Cytogenetic5q31.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW53.3 kDa
Expression TrueORF CloneRC204925
DescriptionHARS2 Full-Length MS Protein Standard (NP_036340), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene.

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