IRF4 Full-Length MS Protein Standard


Product Description:

Name IRF4 Full-Length MS Protein Standard
Cat# CPFL304876
Protein Nameinterferon regulatory factor 4
SymbolIRF4
SynonymsLSIRF; MUM1; NF-EM5; SHEP8
AccessionNM_002460
Cytogenetic6p25-p23
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW51.6 kDa
Expression TrueORF CloneRC204876
DescriptionIRF4 Full-Length MS Protein Standard (NP_002451), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.

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