PCK1 Full-Length MS Protein Standard


Product Description:

Name PCK1 Full-Length MS Protein Standard
Cat# CPFL304758
Protein Namephosphoenolpyruvate carboxykinase 1 (soluble)
SymbolPCK1
SynonymsPEPCK-C; PEPCK1; PEPCKC
AccessionNM_002591
Cytogenetic20q13.31
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW69 kDa
Expression TrueORF CloneRC204758
DescriptionPCK1 Full-Length MS Protein Standard (NP_002582), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized.

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