UBA3 Full-Length MS Protein Standard
Product Description:
| Name |
UBA3 Full-Length MS Protein Standard |
| Cat# |
CPFL304675 |
| Protein Name | ubiquitin-like modifier activating enzyme 3 |
| Symbol | UBA3 |
| Synonyms | hUBA3; NAE2; UBE1C |
| Accession | NM_003968 |
| Cytogenetic | 3p14.1 |
| Amino Acid Labeled | [U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys |
| Chemical Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Expression Host | Human HEK293 cells |
| Predicted MW | 51.7 kDa |
| Expression TrueORF Clone | RC204675 |
| Description | UBA3 Full-Length MS Protein Standard (NP_003959), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
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