CYP2C8 Full-Length MS Protein Standard


Product Description:

Name CYP2C8 Full-Length MS Protein Standard
Cat# CPFL304605
Protein Namecytochrome P450, family 2, subfamily C, polypeptide 8
SymbolCYP2C8
SynonymsCPC8; CYPIIC8; MP-12/MP-20
AccessionNM_000770
Cytogenetic10q23.33
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW55.6 kDa
Expression TrueORF CloneRC204605
DescriptionCYP2C8 Full-Length MS Protein Standard (NP_000761), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene.

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